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Care after steroid injection in knee8/12/2023 Outcomes were measured at baseline, week 2 (exercise start), week 14 (exercise stop), and week 26 (follow-up). Secondary outcomes included the remaining KOOS subscales and objective measures of physical function and inflammation. Main Outcomes and Measures The primary outcome was change in the Pain subscale of the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire (range, 0-100 higher scores indicate greater improvement) at week 14. Two weeks after the injections, all participants started a 12-week supervised exercise program. Interventions Participants were randomly allocated (1:1) to an intra-articular 1-mL injection of the knee with methylprednisolone acetate (Depo-Medrol), 40 mg/mL, dissolved in 4 mL of lidocaine hydrochloride (10 mg/mL) (corticosteroid group) or a 1-mL isotonic saline injection mixed with 4 mL of lidocaine hydrochloride (10 mg/mL) (placebo group). The participants had radiographic confirmation of clinical OA of the knee, clinical signs of localized inflammation in the knee, and knee pain during walking (score >4 on a scale of 0 to 10). Objective To assess the clinical benefits of an intra-articular corticosteroid injection given before exercise therapy in patients with OA of the knee.ĭesign, Setting, and Participants We performed a randomized, blinded, placebo-controlled clinical trial evaluating the benefit of intra-articular corticosteroid injection vs placebo injection given before exercise therapy at an OA outpatient clinic from October 1, 2012, through April 2, 2014. Combined nonpharmacologic and pharmacologic treatments are recommended as the optimal treatment approach, but no evidence supports the recommendation. Importance Osteoarthritis (OA) of the knee is the most frequent form of arthritis and a cause of pain and disability.
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